The big advantage of Macrobid, since it contains nitrofurantoin monohydrate, is that it can be dosed less often than Macrodantin and is equally effective in treating urinary tract infections. Macrobid contains 25% percent of the macrocrystalline form and 75% of the monohydrate form.ДЄs Macrobid capsules are 100mg, this equates to each capsule containing 25 mg nitrofurantoin macrocrystals and 75 mg nitrofurantoin monohydrate. It is available in three different strengths: Macrodantin contains only nitrofurantoin macrocrystals. The prescribing information for Macrobid states this property of nitrofurantoin monohydrate as follows: '.nitrofurantoin monohydrate contained in a powder blend which, upon exposure to gastric and intestinal fluids, forms a gel matrix that releases nitrofurantoin over time.' Macrobid Prescribing Information Macrobid Vs. This gel-like matrix significantly slows the absorption of nitrofurantoin and it is released slowly over time. Once nitrofurantoin monohydrate comes into contact with the gastric juices in the stomach, it forms 'a gel-like' matrix. The monohydrate form of nitrofurantoin was approved by the FDA in 1991 and is even more slowly absorbed than the macrocrystals due to how it reacts when it reaches our stomach.

Nevertheless, although it absorbs more slowly, it is still metabolized and excreted from our system quickly and requires four times a day dosing to be effective. The nitrofurantoin macrocrystalline form was approved by the FDA in 1970 as Macrodantin and was far better tolerated regarding side effects than the microcrystal form as it absorbs slower. We'll start with nitrofurantoin macrocrystals since both Macrobid and Macrodantin contain it.

Moving on to the available drugs, as stated above, Macrobid (nitrofurantoin monohydrate/macrocrystals) has two forms of nitrofurantoin while Macrodantin (macrocrystals) has one. Nitrofurantoin as a drug was approved by the FDA in 1953 as the brand name drug ' Furdantin'.ДЇurdantin actually contained nitrofurantoin microcrystals and while effective in treating urinary tract infections, it tended to cause significant gastrointestinal side effects, such as nausea and vomiting. Over time, there has been quite an evolution in nitrofurantoin products. I discuss these differences and more in detail in the below sections. Macrobid is dosed twice daily while Macrodantin is dosed four times daily.Macrodantin contains one form of nitrofurantoin (macrocrystalline) while Macrobid comprises of two types of nitrofurantoin (macrocrystalline and monohydrate).There are two main differences between them: Both contain the same active ingredient, nitrofurantoin (although in different forms), and are used for the treatment of urinary tract infections. Two such drugs are Macrobid and Macrodantin. This confusion can occur for a multitude of reasons, including similarities in drug name (The Institute for Safe Medication Practices has a comprehensive list of commonly confused drugs) and variations in dosage form or composition. There are numerous drugs on the market that can cause confusion, both among medical professionals or non-medical professionals alike. Macrobid is generally considered the drug of choice since it can be dosed twice daily (instead of four times daily for Macrodantin) and causes less gastrointestinal side effects.Macrodantin contains nitrofurantoin in the macrocrystalline form.В Macrobid contains nitrofurantoin in two forms, macrocrystalline and monohydrate.

Nitrofurantoin mono macro 100mg capsule